PLPPR3 and the making of neuronal filopodia

Abstract

Phospholipid phosphatase-related protein 3 (PLPPR3) is a regulator of neuronal membrane dynamics and cytoskeletal remodeling. In this review, we synthesize current evidence positioning PLPPR3 as a key driver of neuronal filopodia formation, highlighting its roles in lipid signaling, membrane protrusion and actin organization. By consolidating recent molecular, cellular, and functional studies, we propose a mechanistic framework for PLPPR3-dependent filopodia formation and outline its implications for neuronal morphogenesis.