DOI: 10.1093/ofid/ofag705 ISSN: 2328-8957
Pilot Randomized Trial of Patient-Directed vs Fixed-Antibiotic Duration in Acute Pyelonephritis
Brett Faine, Gregory Moran, Anusha Krishnadasan, Anne Zepeski, Ruoyu Li, William Mower, Scott Evans, Jesus Torres, Frank LoVecchio, Nicholas Mohr, Vance Fowler, David TalanABSTRACT
In this multi-center double-blind pilot randomized trial, patient-directed antibiotic duration after symptom resolution demonstrated similar sustained clinical resolution and adverse events compared to fixed-duration treatment among women with pyelonephritis. These findings support the feasibility of this strategy and justify a larger adequately powered randomized trial to evaluate efficacy and safety.