DOI: 10.1039/d6qm00766j ISSN: 2052-1537

Photothermally-triggered phase-change nanoreactors enable spatiotemporally controlled “singlet oxygen storm” for enhanced tumor combination therapy

Kai Long, Xinxin Yuan, Chang Yin, Wei Wang, Zhi Yuan

A persistent luminescence-guided cascade nanoreactor ZAPDP enables self-amplifying ROS catalytic tumor therapy. Au 1 Pd 3 nanozymes trigger SOD-MPO cascades to build an O 2 /O 2 ˙ − feedback loop for sustained singlet oxygen and potent tumor inhibition.

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