DOI: 10.1021/acs.joc.6c01273 ISSN: 0022-3263
Phosphine-Mediated Divergent Cascade Cycloaddition of Cyclic Diketones and Terminal Alkynes: Access to Diverse Pyran-Fused Polycycles
Yu-Lin Zhang, Han-Han Kong, Tian-Yu Long, Wen-Li Xu, Nianyu Huang, Zheng Yang, Qing-Qing Yang, Fen Tan, Long WangAbstract
A facile phosphine-mediated divergent cascade cycloaddition was developed to construct diverse pyran-fused polycycles from cyclic diketones and electron-deficient terminal alkynes. This reaction exhibits alkyne-tuned divergent reactivity and broad functional group compatibility, applicable to both common 2-arylidene-1,3-indanediones and rarely reported alkylidene dibenzo-β-tropolones. A plausible dual-pathway mechanism was proposed to elucidate the divergent reaction process.