Petromaroside A, an unprecedented natural nucleoside from the sponge Petrosia sp. with potent cytotoxicity and biosynthetic insight

A chemical investigation of the Vietnamese marine sponge Petrosia sp. led to the isolation of a novel nucleoside, petromaroside A (1), featuring an unprecedented C-5′ hydroxymethylated deoxyribose moiety, along with thymidine (2).