Personalized Clinical Workflow for Compression Therapy in Post-Burn Hypertrophic Scars Using 3D Imaging and Computational Modeling: A Feasibility Study

Background: Hypertrophic scarring remains a common and clinically challenging consequence of burn injury. Although compression therapy is widely used, its effectiveness is limited by variability in pressure delivery, lack of personalization and inconsistent treatment protocols. Methods: This prospective single-centre feasibility study included adult patients with post-burn scars following deep partial-thickness or full-thickness injuries. The study was designed as a two-phase workflow. In Phase I, scars were documented using standardized photography and 3D surface scanning and were evaluated using the Vancouver Scar Scale (VSS). Scars were stratified based on a predefined threshold (VSS >6) for progression to intervention. In Phase II, patient-specific compression matrices will be designed from 3D surface data and fabricated using biocompatible material. Computational modeling using finite element analysis (FEA) will be applied to simulate pressure distribution. Follow-up is planned at 1, 3, and 6 months, with the VSS as the primary outcome measure. Results: A total of 27 scars were included. The median VSS score was 7 (IQR 5–8). Based on stratification, 14 scars (51.9%) were eligible for personalized compression therapy. Three-dimensional imaging was feasible in all cases and allowed for improved qualitative visualization of scar morphology compared to standard photography. Preliminary findings support the applicability of the proposed workflow, while longitudinal outcome analysis is ongoing. Conclusions: This feasibility study presents and evaluates a clinical workflow combining 3D imaging, objective scar stratification, and personalized compression therapy. This approach provides a structured framework for personalized compression therapy, while its clinical effectiveness remains to be established. Further studies are required to evaluate long-term outcomes.