Perioperative Seizures and Quality of Life in Falx and Convexity Meningiomas: Key Factors of Patient Outcomes

Background: Falx and convexity meningiomas can compress surrounding brain structures, frequently resulting in epileptic seizures, which adversely impact the quality of life (QoL) of affected patients. This study aimed to assess postoperative QoL in patients with documented perioperative seizures associated with falx and convexity meningiomas. Methods: The Quality of Life in Epilepsy Inventory-31 (QOLIE-31) was administered to patients who underwent surgery for falx/convexity meningiomas and experienced perioperative seizures. Seizures were defined as those occurring within 30 days pre- or post-surgery. Results: A total of 77 patients responded to the questionnaire, of whom 44 were female and 33 were male. Multivariable analysis showed that falx meningioma was associated with a lower QOLIE-31 score (OR = 4.02, 95% CI: 1.14–14.18, p = 0.03). Furthermore, the presence of peritumoral edema was also associated with lower QOLIE-31 scores (OR = 3.89, 95% CI: 1.04–14.47, p = 0.043). Conclusions: This study demonstrates that perioperative seizures in patients with falx meningiomas significantly impact postoperative quality of life. The presence of peritumoral edema was also associated with poorer QoL outcomes. These findings underscore the importance of targeted management strategies to to improve QoL in meningioma patients experiencing seizures.