DOI: 10.1039/d6lc00266h ISSN: 1473-0197
Perfused brain slice-on-chip platforms: a systematic review of long-term organotypic hippocampal tissue culture
Tando Maduna, Anna Pancho, Yasin Ilgaz, Marsela Hakani, Atocha Guedán-Duran, Alan Morin, Julia Elisa Sepulveda-Diaz, Assunta Virtuoso, Ciro De Luca, Giovanni Cirillo, Michele Papa, Fivos Panetsos, José Pérez-Rigueiro, Andreas VlachosPerfused brain-on-chip platforms preserve tissue viability, structure and electrophysiological activity. No validated long-term adult or human brain OoCs exist, highlighting a need for advanced functional readouts and translational applications.