PerfSCORE as a Predictor of Early Mortality in Open-Heart Surgery: Comparative Evaluation with NIRS and S100B
A Koçarslan, ZAA Onuk, S Kulaksızoğlu, G Özerdem, H Yılmaz, MS AydınBackground:
This study aims to investigate the correlation between NIRS and S100B, and the effects of NIRS, S100B, and PerfSCORE parameters on morbidity and mortality in patients undergoing open-heart surgery who had their cardiopulmonary bypass (CPB) flow volume adjusted using NIRS.
Methods:
In this prospective study, 60 adult patients undergoing open-heart surgery between January and June 2024 were enrolled. Intraoperative NIRS values were recorded at baseline, at the initiation of cardiopulmonary bypass (CPB), at CPB termination, and at the end of surgery for both cerebral hemispheres. Serum S100B levels were measured preoperatively (T1), and postoperatively at 6 hours (T2) and 24 hours (T3). Correlation analyses were performed between NIRS values and S100B levels. In addition, the effects of S100B, NIRS, and PerfSCORE on mortality and morbidity were compared.
Results:
A total of 73 procedures were performed in 60 patients. A weak negative correlation was found between early NIRS values and postoperative S100B levels (
Conclusion:
Although weak correlations exist between cerebral oxygenation and S100B levels, S100B protein alone does not appear to be a reliable marker for early mortality. PerfSCORE parameters demonstrated greater predictive value and clinical utility.