Patients with Ileal Pouch-Anal Anastomosis Have Decreased Bowel Frequency on Glucagon-like Peptide-1 Receptor Agonist Therapy
Ezan Chaudhry, Payal Kakadiya, Hayden Vaughn, Simon Gray, Jonathan J. Hansen, John P. Haydek, Animesh Jain, Millie D. Long, Hans H. Herfarth, Edward L. BarnesBackground:
High bowel frequency after ileal pouch-anal anastomosis (IPAA) causes significant symptom burden. We aimed to evaluate the impact of GLP-1 receptor agonists (GLP1RAs) in this setting.
Methods:
We conducted a retrospective cohort study of patients with prior IPAA for ulcerative colitis who were treated with a GLP1RA (n=20). Daily bowel frequency at baseline and 12 weeks after GLP1RA initiation was assessed. We also assessed the proportion of patients achieving ≥30% reduction in bowel frequency and ≤8 bowel movements per day.
Results:
Median daily bowel frequency decreased from 9.0 (IQR, 6.0-12.5) at baseline to 6.0 (IQR, 5.0-8.1) at the 12-week follow-up (p<0.01). Overall, 7 of 20 patients achieved a ≥30% reduction in bowel frequency, and 15 of 20 had ≤8 bowel movements per day.
Conclusion:
In this retrospective cohort, we provide further evidence for the potential role of GLP1RAs in the management of high bowel frequency after IPAA.