DOI: 10.1084/jem.20261409 ISSN: 0022-1007

Parkinson’s at the brain border

Henry Kim, Tsogt-Itgel Munkhbat, Max A. Tischfield

Parkinson’s disease is increasingly recognized as a disorder that extends beyond neurons. In this issue of JEM, Stevenson et al. (https://doi.org/10.1084/jem.20251245) highlight the functional consequence of α-synuclein aggregates at the brain border, uncovering their active role in reshaping lymphatic integrity and the neuroimmune macroenvironment.

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