DOI: 10.1097/in9.0000000000000091 ISSN: 2633-0407
Palmitate drives an epigenetic dead end in CD8 T cells
Johannes Schroth, Sian M. Henson
The tumor microenvironment (TME) plays a critical role in promoting tumor immune evasion and limiting cancer therapy efficacy. A fatty-acid-rich TME not only supports tumor survival but also immune suppression. Cytotoxic T lymphocytes (CTLs) are particularly dependent on environmental nutrients. A recent study by Tiberti et al published in
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