DOI: 10.3390/molecules31152724 ISSN: 1420-3049
Palladium(II)/Norbornene Cooperative Catalysis for Regioselective C–H Silylation Toward Diversified Silylindoles
Wenguang Li, Xinfeng Cheng, Qi Suo, Ke Hu, Yuqing Wang, Jianguang Zhu, Yongqi YuA strategy for the selective C–H silylation of 7-phenyl-1H-indoles has been established via palladium(II)/norbornene cooperative catalysis. This method employs norbornene (NBE) as both a C–H activation mediator and an alkylating agent to access arylsilanes with exceptional selectivity. Kinetic isotope effect (KIE) studies revealed that C–H cleavage is the rate-determining step, consistent with a mechanism proceeding through an eight-membered palladacycle.