DOI: 10.1021/acs.orglett.6c03967 ISSN: 1523-7060
Palladium-Catalyzed Domino [3 + 2] Cyclization and C–P/C–B Bond Construction Employing (2-Bromoaryl)boronates as C2 Synthons
Yiyi Zheng, Yu Meng, Tao Chen, Haoyu Cheng, Yanxiu Chen, Jingwen Xi, Xin-Xing WuAbstract
A palladium-catalyzed multicomponent cascade reaction involving o-iodostyrenes, (2-bromoaryl)boronates, and H-phosphonates or bis(pinacolato)diboron has been developed. The reaction features sequential Suzuki–Miyaura coupling, Heck cyclization, and C–P/C–B bond construction, wherein (2-bromoaryl)boronate acts as a dual coupling partner to overcome the inherent regioselectivity limitations of its aryne precursor pathway.