DOI: 10.1055/a-2991-3391 ISSN: 0039-7881

Palladium-Catalyzed Deoxygenative Deuteration of Aryl Nonaflates

Reo Wakiyama, Masami Kuriyama, Kotaro Tsukuda, Kazuya Kamata, Tetsuro Morimoto, Kosuke Yamamoto, Yosuke Demizu, Osamu Onomura
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The palladium-catalyzed synthesis of deuterated aromatics through deoxygenative deuteration of aryl nonaflates has been achieved in good to high yields with high D contents. In this process, a variety of functional groups and heterocyclic moieties were well tolerated, and the double incorporation of deuterium also proceeded smoothly. As well as the synthesis of a deuterated estrone derivative, the gram-scale experiment was conducted with sufficient efficiency, showing the promising potentiality of this method.

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