P1248 Higher Life’s Essential 8 score is associated with reduced risk of IBD-related surgery and all-cause mortality among 3,232 individuals with inflammatory bowel disease in a prospective cohort study
F Jing, Y Cao, Q Gong, L Dan, Y Zhu, F Magro, T Fu, X Wang, J ChenAbstract
Background
Previous studies indicated lifestyles that benefit cardiovascular health, are associated with the risk of prognosis in inflammatory bowel disease (IBD), while evidence lacked regarding the impact of cardiovascular health as a whole. We aimed to explore the potential longitudinal association between the overall cardiovascular health indicator, Life’s Essential 8 (LE8), and the adverse outcomes of IBD.
Methods
Using data from the UK Biobank, we included 3,232 individuals with IBD recruited in 2006–2010. The components of LE8, including diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure, were measured and given a score of 0–100. The LE8 score for each individual was the mean score of all components and was divided into three levels: low (0–49), moderate (50–79), and high (80–100). The adverse outcomes studies in our study included IBD-related surgery and all-cause mortality, ascertained via primary care, hospital inpatient data, and death registry. Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for the magnitude of the associations.
Results
Among the 3,232 individuals with IBD, 1,579 were female (49%) and 2,227 were with UC (69%). Over a mean (standard deviation) follow-up of 12.60 (2.74) years and 13.17 (1.89) years, 282 IBD-related surgery and 259 death events were documented. Among participants with UC, compared to participants with low LE8 score, the HRs (95% CIs) of those with high score for IBD-related surgery and all-cause mortality were 0.47 (0.26, 0.87) and 0.47 (0.25, 0.87). Similar inverse associations were demonstrated from the competing risk model between LE8 score and IBD-related surgery among individuals with UC. In addition, we did not observe any significant associations of LE8 score with the risk of IBD-related surgery and all-cause mortality among CD. The above associations were robust in sensitivity analyses when further adjusted for aminosalicylate use, corticosteroid use, immunomodulator use, CRP concentration, or baseline IBD duration separately.
Conclusion
Conclusion: Participants with higher LE8 score showed decreased risk of IBD-related surgery and all-cause mortality among individuals with UC, but not CD, highlighting the important role of adopting LE8 in improving the prognosis of UC. Future randomized control studies are needed to confirm the effect of enhancing LE8 score to reduce the risk of IBD-related surgery and all-cause mortality and better manage the disease course of IBD.