P0492 Development and Assessment of a Novel Ulcerative Colitis–Specific Quality of Life Questionnaire: A Prospective, Multi-Institutional Study

Background

Interest in the quality of life (QoL) of patients with inflammatory bowel disease (IBD) has recently increased. Althoughmeasurement tools have been devised for IBD in general, there is no specific tool for measuring the QoL of patients with ulcerativecolitis (UC). Therefore, we developed a QoL questionnaire specifically for patients with UC.

Methods

The Korean Ulcerative Colitis-Specific Questionnaire (K-UCSQ) was developed through item generation,raw-scale construction, focus group meetings, and multi-center field tests. Two hundred patients with UC were recruited for a fieldtest of the K-UCSQ, and subsequent responses to the Inflammatory Bowel Disease Questionnaire (IBDQ) were also obtained. Afterperforming factor analyses to ensure construct validity, the K-UCSQ was finalized as a four-domain, 28-item questionnaire. Subsequentanalyses evaluated the reliability of the K-UCSQ in terms of Cronbach’s alpha, concurrent validity in comparison with thepre-established IBDQ, and predictive validity of the area under the ROC curve (AUC) for clinically relevant QoL outcomes.

Results

A Cronbach’s alpha of 0.94 showed excellent reliability. Furthermore, correlation analyses demonstrated the concurrent validityof the K-UCSQ in comparison with the IBDQ. The K-UCSQ also showed high validity in predicting the perceived overall health(AUC of 0.812 vs. 0.797 using the IBDQ) and past 2-week QoL (AUC of 0.864 vs. 0.859 using the IBDQ).

Conclusion

The newly developed K-UCSQ is concise, bathroom problem-emphasizing, and UC-specific, suggesting that it couldbe a valid and reliable UC-specific instrument for QoL measurement.

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