P-461: Triggering factors of ketoacidosis in type 1 diabetes in Niger
M S Mahamane Aminou, M I Abdoulwahab, M B AboubacarAbstract
Introduction
Type 1 diabetes is a rare but common condition, the management of which is often complicated by acute events such as ketoacidosis.
Objectives
The aim of this study was to identify the triggering factors of ketoacidosis in type 1 diabetes in our setting.
Methods
This was a prospective, descriptive, multicenter study conducted from January 1, 2024, to December 31, 2025 (2 years).
Results
We collected data on a total of 119 diabetic patients aged 0 to 20 years, of whom 61 (51.2%) had ketoacidosis. The mean age of the patients was 16.90 ± 4.48 years (range 2-20 years). The male-to-female ratio was 0.51. The mean duration of diabetes was 4.33 ± 1.7 years. Diabetes was discovered in 59.8% of cases due to complications, and in 40.2% due to cardinal symptoms. Among the factors triggering the infection, 62.2% were malaria (32.8%), followed by treatment discontinuation (50.8%), lack of financial resources (8.2%), and improper insulin storage (8.2%). Insulin therapy consisted of two injections of mixed insulin in 72.9% of cases. 51% of patients had a blood glucose meter.
Conclusions
Type 1 diabetes is common but often complicated by ketoacidosis. The most frequent triggering factors were infection, treatment discontinuation, and improper insulin storage. Triggering factors, ketoacidosis, T1D, Niger