P-307: Clinical profile and glycemic control in children and adolescents with type 1 diabetes (T1D) and autism spectrum disorder (asd) in a specialized center
I Ferraz dos Santos, L Cudízio, R Biasi, L E CalliariAbstract
Introduction
T1D management in children with ASD may be challenging due to behavioral and sensory barriers, which may compromise adherence and the achievement of optimal glycemic control. However, data on clinical characteristics and glycemic outcomes in this population remain limited.
Objectives
To describe clinical characteristics and glycemic outcomes among pediatric patients with T1D and ASD.
Methods
This retrospective descriptive study analyzed medical records of pediatric patients with T1D and ASD at a specialized center in São Paulo, Brazil. Collected data included demographics, BMI, insulin regimen and dosage, glucose monitoring, HbA1c, time in glycemic range (TIR), acute complications over the past year, chronic complications, and ASD medication use.
Results
Eight patients were included, mostly male (87.5%), with an average age of 10.5 years (SD 3.29). The average HbA1c was 8.4% (1.19), and the mean TIR was 41.5% (19.0). BMI z-score ranged from -0.33 to +2.69. The majority used multiple daily injections (87.5%), with 25% using CGM technology. The mean insulin dose was 1.13 IU/kg/day (0.34). Acute complications involved one episode of severe hypoglycemia with seizure, with no cases of diabetic ketoacidosis. One patient exhibited elevated albuminuria. Use of ASD medication was common, present in 62.5%.
Conclusions
Patients with T1D and ASD exhibited sub-optimal glycemic control, limited technology use, and may experience acute complications apparently comparable to those of the non-ASD T1D group. This underscores the importance of personalized, multidisciplinary care. Comparison with children with T1D without ASD and QoL questionnaires are being evaluated and may bring more information to this new and increasing association.