P-261: Real-World data on automated BOLUS support tools and glycemic outcomes in children and adolescents with type 1 diabetes mellitus in Argentina
M.L. kabakian, D Contreras, A Portnoy, F Oliva, S Carbajal, D Oropeza, P Mariana, M S Fowler, A FloresAbstract
Introduction
Automated insulin delivery systems have transformed the management of type 1 diabetes mellitus (T1DM) in the pediatric population, improving glycemic control and reducing treatment burden. The integration of support tools such as AutoMeal® into the NanoTouchCare® system (Medtrum) aims to optimize mealtime dosing, especially in children and adolescents, in whom variability in food intake and adherence pose significant challenges. However, real-world evidence on its impact in the Latin American pediatric population remains limited.
Objectives
(1) To evaluate the impact of AutoMeal® use on glycemic control parameters in pediatric patients using NanoTouchCare®; (2) To analyze adherence based on the percentage of daily AutoMeal® use.
Methods
Observational, retrospective, real-world study including children and adolescents living with T1DM aged 2-18 years, assisted in 3 centers in Argentina and using the NanoTouchCare® system (≥3 months in automatic mode, ≥1 month of AutoMeal® use.
Results
Twenty-nine children and adolescents living with T1DM were included (age: 13±3.4 years, female: 55.17%). Use of Automeal® was associated with high time in range (median: 74% (interquartile range [IQR]: 63-91) and time in tight range (median: 51% [36-74]; low time above range > 180 mg/dL (median: 18% [16-21.1]) and time below range < 70 mg/dL (median: 1% [0.5-1.3]). The glucose management indicator (median: 7% [6.8-7]) and the coefficient of variation (median 35% [32.4-37.5]) were within adequate ranges. Adherence was high (median 93% [74.3-97.9]) and only 6/29 patients (20.7%) exhibited low or moderate adherence. Female patients showed a non-significant trend for higher adherence vs. males (p=0.06). Time since initiation of Automeal® was inversely correlated with adherence (r=-0.395, p=0.034).
Conclusions
In a Latin American real-world setting, children and adolescents with T1DM are highly adherent to support tools, with a positive impact on glycemic parameters.