P-104. Impact of Sepsis-Induced Cardiomyopathy on Clinical Outcomes in Sepsis Patients
Tae Wan Kim, Ryoung-Eun KoAbstract
Background
Despite the known impact of cardiac function on sepsis outcomes, there is limited understanding of how ejection fraction (EF) influences hospital mortality in patients with sepsis-induced cardiomyopathy. This study assesses the severity of cardiac dysfunction determined by echocardiography within the first 24 hours of sepsis diagnosis on hospital mortality.
Methods
In this retrospective cohort study, 2,504 patients diagnosed with sepsis and who underwent echocardiography within 24 hours were analyzed. Based on EF, patients were classified into normal (EF ≥ 50%), moderate dysfunction (30% ≤ EF < 50%), and severe dysfunction (EF < 30%). The primary outcome was hospital mortality. Multivariable logistic regression was employed to identify factors associated with increased mortality, adjusting for clinically and statistically significant variables.
Results
Among the study patients, 1,803 (72%) had a normal EF, 356 (14.2%) had moderate dysfunction, and 115 (4.6%) had severe dysfunction. The hospital mortality was significantly higher in the severe dysfunction group at 40.0%, compared to 29.5% in moderate and 25.7% in normal EF groups (P=0.023). In multivariable analysis, severe cardiac dysfunction, inappropriate initial antibiotic therapy, and certain sites of infection were significantly associated with increased hospital mortality.
Conclusion
The decreased EF among sepsis patients is correlated with increased organ failure and higher mortality rates compared to patients with normal cardiac function.
Disclosures
All Authors: No reported disclosures