Outpatient Infusion Therapy for Pediatric Status Migrainosus: Real-World Clinical Outcomes From a Tertiary Care Center

Pediatric patients with status migrainosus frequently present to the emergency department for acute treatment, despite growing evidence that outpatient infusion centers are associated with pain reduction and high patient satisfaction in adults. In this single-center study, 19 patients with status migrainosus were prospectively enrolled prior to outpatient infusion with intravenous normal saline, ketorolac, and antiemetic (prochlorperazine or metoclopramide), followed by valproic acid if pain score did not reach 0/10. Patients completed pre- and post-infusion surveys. All patients had reduced pain intensity scores after infusion, with an average pain reduction of 4.3 points on a 0- to 10-point scale ( P  < .001). Infusion was associated with a significant decrease in photophobia ( P  = .008) and phonophobia ( P  = .02). Although compliance with follow-up survey was low, 100% (6/6) of respondents reported they would consider outpatient infusion for future episodes of status migrainosus. These findings suggest that outpatient infusion for pediatric status migrainosus is a feasible alternative to the emergency department.