Ordinal Deep Learning for Lumbar Foraminal Stenosis Grading on Sagittal MRI

Lumbar foraminal stenosis grading contributes to surgical-level selection, but automated four-grade classification remains challenging. Published pipelines for this dataset reach approximately 65% four-class accuracy, and deep classifiers offer no anatomical rationale. We investigated whether interpretable, millimeter-scale morphometry from segmentation masks improves grading beyond a deep image model. We analyzed the LSS-MRI-AISSLab sagittal T2-weighted dataset (469 patients, 2979 expert-graded foramina spanning L1-L2 through L5-S1 bilaterally on a four-grade scale). Ten morphometric descriptors were computed from mid-sagittal polygon segmentations and scaled to millimeters using each patient’s recorded pixel spacing. A dual-branch network combined a fine-tuned ResNet-18 embedding of each foraminal region of interest with the morphometric vector through an ordinal regression head. Foraminal regions were supplied from expert bounding-box annotations; automated localization within the full sagittal examination was not evaluated. Four configurations (nominal softmax, appearance-only, anatomy-only, and fusion) were compared on a locked patient-level test set of 94 patients after five-fold cross-validation, with quadratic weighted kappa (QWK) as the primary endpoint and patient-clustered bootstrap inference. Feature-grade correlations were reported pooled and adjusted for lumbar level. Fusion achieved QWK 0.813 (95% confidence interval [CI] 0.769–0.847) and 75.3% four-class accuracy. Appearance-only was statistically indistinguishable (QWK 0.806; delta QWK +0.006, 95% CI −0.023 to 0.036, p = 0.68), whereas anatomy-only reached 0.444, and a level-and-side-only reference reached 0.314. Boundary discrimination was strong (area under the curve 0.92–0.99), 98.3% of predictions fell within one grade, and performance was consistent across scanner vendors. Morphometric associations were confounded by level: the apparent spondylolisthesis effect (rho −0.349) disappeared after adjustment (rho −0.000), while disc height, null when pooled (rho +0.021), emerged as a genuine within-level effect (rho −0.108). A fine-tuned ordinal image classifier achieved strong agreement for four-grade lumbar foraminal stenosis classification. The evaluated segmentation-derived morphometric features did not improve performance beyond imaging alone, and several apparent anatomic associations reflected confounding by lumbar level. External and prospective validation in complete clinical MRI workflows are needed before implementation.