DOI: 10.2807/1560-7917.es.2026.31.25.2600460 ISSN: 1560-7917
Ongoing multi-country outbreak of carbapenem-resistant Enterobacter hormaechei ST1344 carrying bla NDM-5 in the European Union/European Economic Area, March 2025 to April 2026
Louise Roer, Mirco Sandfort, Sebastian Haller, Sarah A Roth, Lisa-Marie Höfken, Soheila Javadi, Núria Balanza, Amelie Friedsam, Silver A Wolf, Claus Østergaard, Monica T Y Wong, Joanna Lis-Tønder, Annelot F Schoffelen, Martin Cormican, Lone Jannok Porsbo, Christina Clarke, Henrik Hasman, Heidrun Kerschner, Anette M Hammerum, Rainer Hart, Ørjan Samuelsen, Miriam Sare, Marie Meo, Anne-Sophie Lagneaux, Monique Perrin, Vilhelm Müller, Sandra Witteveen, Sabine C de Greeff, Daan W Notermans, Olov Svartström, Erik Alm, Marius Linkevicius, Anke Kohlenberg, Antoni P A HendrickxIn seven EU/EEA countries, the emergence of NDM-5-producing Enterobacter hormaechei ST1344 among patients has been detected. In minimum spanning tree analysis of core genome-multilocus sequence-typing (cgMLST) profiles, isolates cluster with ≤ 4 allelic differences. The outbreak includes 57 cases (29 female/28 male; median age: 73 years), which occurred between March 2025 and April 2026. Many were hospitalised (n = 45), some with extensive prior medical treatment, and only three reported travel abroad. A cross-border investigation, including coordinated exposure questionnaires, has not yet identified a source.