One‐Pot Domino C ─ N / C ─ C Cross‐Coupling Approach: Access t

ABSTRACT

A transition metal‐catalyzed domino C ─ N / C ─ C cross‐coupling strategy for the efficient construction of heterocyclic frameworks has been developed. The reaction proceeds smoothly under mild conditions enabling the formation of cross‐coupling reaction through a single‐step cyclization process. A broad range of substrates bearing electron‐donating and electron‐withdrawing substituents were well tolerated, affording the desired heterocyclic products in moderate to good yields. Notably, halogen‐substituted substrates remained intact under the optimized conditions, demonstrating excellent chemoselectivity and functional group compatibility. The operational simplicity, substrate generality, and mechanistic clarity highlight the synthetic utility of this protocol for the rapid assembly of structurally diverse heterocyclic scaffolds.