DOI: 10.1093/chemle/upag106 ISSN: 0366-7022
On the origin of selectivity in nitrene C–H insertion reactions
Radim HrdinaAbstract
The C–H bond is considered a functional group that can be substituted on demand. If the substituent is a nitrogen-containing moiety introduced via a nitrene insertion, the process is known as an amination. The selectivity of such reactions may depend on the reactivity of the substrate, or it can be controlled. In this review, we focus on the directed insertion of nitrenes into C–H bonds in substrates, investigating the options available for influencing the selectivity of these processes.