O-01: Nationwide incidence trends of type 1 diabetes in children and adolescents in Bangladesh: a 15-year multi centre Population-Based study (2010–2024)
B Zabeen, K Huda, M M Rahman, A Hasan Flabe, M A Habib, M S Islam, K AzadAbstract
Introduction
Population-based data on paediatric type-1 diabetes (T1D) remain limited in low-and middle-income countries. In Bangladesh, the absence of a national registry may contribute to under-ascertainment.
Objectives
The aim of this study was to estimate nationwide incidence and describe temporal, demographic, and geographic variations.
Methods
We conducted a nationwide, multicentre, population-based study leveraging data from 109 diabetes centres across all administrative divisions of Bangladesh from 2010 to 2024. Incident cases were defined as individuals aged 0–19 years diagnosed with T1D and requiring insulin at presentation. Incidence rates per 100,000 population were estimated using age-specific census denominators. Temporal trends in incidence were analysed using Poisson regression models.
Results
A total of 6,667 paediatric T1D cases were identified (2010–2024). Overall incidence increased modestly 0.63 to 0.70 per 100,000). However, the pattern was not uniform, with a steady decline through 2020, followed by a marked increase from 2021 to 2024 (IRR 1.09, 95% CI 1.04–1.13; p<0.001). Incidence highest among aged 10–14 years and was lowest among children aged 0–5 years. Females predominated (male-to-female ratio 1:1.54). Marked geographic heterogeneity was observed, with the highest incidence in Dhaka Division (3.46 per 100,000) and the lowest in Sylhet Division (0.23 per 100,000).
Conclusions
Paediatric T1D incidence in Bangladesh remains low in the global context but demonstrates a recent increasing trend and marked regional disparities. These findings highlight an evolving epidemiological pattern and underscore the urgent need for robust national surveillance and targeted public health interventions.