DOI: 10.1002/poc.70111 ISSN: 0894-3230

Nucleophilic Aromatic Substitution in the Gas Phase

Daniel N. Hirsch, Damon J. Hinz, Jeehiun K. Lee

ABSTRACT

In this review, we highlight experimental studies of gas‐phase nucleophilic aromatic substitution (S N Ar). S N Ar is a reaction of great utility and import, and studies in the gas phase present a unique opportunity to ferret out intrinsic reactivity. The literature in this field spans over 50 years. This review provides historical context from which to assess findings and possible future directions in the field.

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