DOI: 10.1039/d6md00416d ISSN: 2632-8682
Novel triazolo[1,5]benzodiazepines as potent dual AChE/BChE inhibitors for Alzheimer's disease: synthesis, characterization, in vitro and in silico studies
Marouane Ait Lahcen, Halil Şenol, Saad Zekri, Nastaran Sadeghian, Samir Hmaimou, Laura Chelazzi, Samuele Ciattini, Elena Zaballos-García, Parham Taslimi, Ismail Hdoufane, Driss Cherqaoui, Abdesselam Baouid, Mohamed AdardourTargeting Alzheimer's disease, a cycloaddition route furnishes triazolo[1,5]benzodiazepines with potent, picomolar dual AChE/BChE inhibition, validated by X-ray, NMR, HRMS, and molecular docking.