DOI: 10.1039/d6dt00693k ISSN: 1477-9226
Novel ruthenium(
ii
) complexes bearing polypyridyl and 1,2,4-oxadiazole ligands: from synthesis to
in vitro
and
in vivo
Laura Marretta, Daniel Valcanover, Maria Pia Buono, Christine Pirker, Sara Amata, Bernhard K. Keppler, Antonio Palumbo Piccionello, Alessio Terenzi, Walter Berger, Giampaolo Barone Ru(
ii
) polypyridyl complexes featuring unprecedented chelating 1,2,4-oxadiazoles were synthesized and characterized. Phenanthroline derivatives show enhanced activity against platinum-resistant cancer cells, with good
in vivo
tolerability.