DOI: 10.1039/d5ra05647k ISSN: 2046-2069

Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies

Hina Zaman, Aamer Saeed, Uzma Azam, Ghulam Shabir, Madiha Irfan, Basant Farag, Hesham R. El-Seedi

Novel guanidines are synthesized as DNA minor groove binders. Spectroscopic and DFT studies revealed that EDGs synergize with halogens to enhance binding affinity, offering promising scaffolds for anticancer drug design.

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