DOI: 10.1002/slct.74819 ISSN: 2365-6549
Nonmetal‐Catalyzed Selective Cycloaddition Reactions of N ‐2,2,2‐Trifluoroethylisatin Ketimines
Fatemeh Doraghi, Mohammad Hadi Edareh, Bagher Larijani, Mohammad MahdaviABSTRACT
Among the developed isatin synthons, N ‐2,2,2‐trifluoroethylisatin ketimine, containing an oxindole and trifluoromethyl deactivating moiety, is known as an efficient and versatile building block in (3+n)‐cycloaddition reactions to construct a wide range of heterolytic spirocyclic compounds. This review highlights various metal‐free organocatalytic and base‐catalyzed systems involving N ‐2,2,2‐trifluoroethylisatin ketimines.