Nonlinear association between waist-to-height ratio and Alzheimer's disease among middle-aged and older adults: A cross-sectional study from NHANES
Bei Li, Tianai Shi, Meidi Yang, Haijing LiuBackground
The association between waist-to-height ratio (WHtR) and Alzheimer's disease (AD) remains unclear in the general population.
Objective
This study aimed to investigate the relationship between WHtR and AD using data from the nationally representative National Health and Nutrition Examination Survey (NHANES).
Methods
This cross-sectional study included participants aged ≥45 years from NHANES. Weighted multivariable logistic regression, restricted cubic spline (RCS), subgroup, and sensitivity analyses were performed to evaluate the association between WHtR (scaled by 10) and AD.
Results
Higher WHtR was significantly associated with greater odds of AD after adjustment for potential confounders (OR = 1.30, 95% CI: 1.18–1.42,
Conclusions
Higher WHtR was significantly associated with greater odds of AD among middle-aged and older adults. A nonlinear U-shaped association was also observed, suggesting that both lower and higher WHtR levels may be associated with increased odds of AD. Further prospective studies are warranted to confirm these findings.