No association of prior administration of selected vaccines with lymphoma prognosis
George A. Cholack, Verena Hinder, Raphael Mwangi, Thomas M. Habermann, Dennis P. Robinson, Melissa C. Larson, Andrew L. Feldman, Thomas E. Witzig, Stephen M. Ansell, Eric Mou, Yucai Wang, Carrie A. Thompson, Matthew J. Maurer, Anne J. Novak, Susan L.. Slager, James R. CerhanAbstract
Background: While some vaccines appear to be associated with lower risk of lymphoma, their impact on outcomes is largely unknown. Methods: Data from a large prospective lymphoma cohort study was utilized to estimate associations of self-reported history of vaccination against hepatitis A, hepatitis B, influenza, and yellow fever with event-free survival (EFS) and overall survival (OS) using Cox proportional hazard models. Results: None of the vaccines were associated with EFS (HRs 0.77-1.00) or OS (HRs 0.96-1.04). Similarly, there were no significant associations between the vaccines and outcome for each lymphoma subtype. Conclusions: Prior vaccination against selected viruses was not associated with EFS or OS among patients with lymphoma. Impact: We did not find evidence for an impact of prior vaccination on lymphoma prognosis.