Nickel‐Catalyzed Cross‐Coupling of Aryl alkyl Selenides with Aryl Bromides: Cross Coupling between two electrophile

A nickel‐catalyzed cross‐coupling reaction has been developed using two distinct electrophiles: an aryl alkyl selenide and an aryl bromide. The organoselenium compound, due to the lower bond dissociation energy of the C‐Se bond, acts as a pseudohalide. This one‐pot reaction proceeds by cleaving the C‐Se bond, producing the desired biaryls in moderate to good yields. This method has the potential to become a valuable tool in organic synthesis, owing to its substrate scope and scalability. Importantly, the use of commercially available aryl bromides eliminates the handling of pre‐formed organomagnesium reagents, enhancing the practicality and applicability of this approach.