Outline
DOI: 10.1055/a-2991-2199 ISSN: 0039-7881
Nickel-Catalyzed C(sp 2 )-H Arylation of Aryl Amides with Aryl Bromide: Synthesis of Telmisartan and Sartan Intermediates
Priyanka Mishra, Ashok Kumar PandeyThe sustainable synthesis of biaryl sartan intermediates has significant potential in the pharmaceutical industry. Herein, nickel catalyzed C(sp²)-H functionalization of aryl amides with aryl bromides has been disclosed and used in synthesis of telmisartan and sartan intermediates. Deuterium exchange, competitive reaction and radical clock experiment support a Ni(II)/Ni(IV) catalytic cycle.
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