Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): A mixed-methods, multi-centre feasibility randomised controlled trial
Roshan das Nair, Gogem Topcu, Nia Goulden, Shaun Harris, Jacqueline R Mhizha-Murira, Haley Morris, Polly Swain, Lauren A Taylor, Jonathan Hancock, Laura Price, Jenna Hill, Avril Drummond, Zoë Hoare, Deborah Fitzsimmons, Denise Kendrick, Stephen Timmons, Shirley Thomas, Jennifer Martin, Rod Middleton, James C Turton, Clare Bale, Andrea Stennett, Rachel Simkiss, Kimberley Fletcher, Emma C Tallantyre, Klaus Schmierer, Nikos Evangelou,Background
Cognitive difficulties are common in people with multiple sclerosis (pwMS), yet access to neuropsychological rehabilitation is often limited or only provided to those with more severe impairments. The NEuRoMS intervention provides brief, tailored neuropsychological rehabilitation for pwMS with mild-to-moderate cognitive difficulties.
Objectives
To evaluate feasibility and acceptability of the intervention and test procedures for a definitive trial.
Methods
A mixed-methods, multi-centre feasibility randomised controlled trial (RCT) was conducted. Feasibility outcomes were recruitment, retention, outcome completion, randomisation, intervention delivery and fidelity. Quantitative data were collected at baseline, 3- and 6-months, supplemented by interviews with pwMS and healthcare providers.
Results
Seventy-nine participants were randomised (mean age = 54.5 (
Conclusion
The NEuRoMS intervention and trial procedures were feasible and acceptable, with early indication of efficacy. A definitive RCT is underway.
Trial registration:
ISRCTN11203922;