DOI: 10.1039/d4ra04941a ISSN: 2046-2069
Neuroprotective thiazole sulfonamides against 6-OHDA-induced Parkinsonian model: in vitro biological and in silico pharmacokinetic assessments
Waralee Ruankham, Ratchanok Pingaew, Veda Prachayasittikul, Apilak Worachartcheewan, Suphissara Sathuphong, Setthawut Apiraksattayakul, Tanawut Tantimongcolwat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat PhopinNovel thiazole sulfonamides revealed capabilities against 6-OHDA-induced neuronal damage via SIRT1 activity. Thus, these neuroprotective thiazole sulfonamides could be promising candidates for the further development of effective PD therapy.