DOI: 10.1111/nan.70099 ISSN: 0305-1846
Neuropathological Findings Following Failure of Laser Interstitial Thermal Therapy for an Epileptogenic Cerebral Cavernous Malformation
Alberto Pietrantoni, Roberta Di Giacomo, Michele Rizzi, Valeria Cuccarini, Fabio Martino Doniselli, Rachele Colombo, Gianluca MarucciSummary
We describe the case of a 32‐year‐old woman with focal drug‐resistant epilepsy who underwent surgical resection of a cerebral cavernous malformation (CCM) previously treated with laser interstitial thermal therapy (LITT), following seizure recurrence. Histological findings after LITT have rarely been described. We report and discuss neuropathological findings that may explain post‐LITT seizure recurrence, focusing on extensive haemosiderin deposition and a small residual component of the original CCM. This illustrative case may improve understanding of the histological basis of LITT failure to provide sustained seizure control.