Nef-adducts (α-keto Imidoyl Chlorides) and their Reaction with 2- Aminopyridines: Synthesis of 2-(4-aryl)-3-(cyclohexylimino)-2-hydroxy2,3-dihydro-1H-imidazo[1,2-a]pyridin-4-ium Chlorides and their Biological Assessment

A group of 2-(4-aryl)-3-(cyclohexylimino)-2-hydroxy-2,3-dihydro-1H-imidazo[1,2- a]pyridin-4-ium chlorides was successfully synthesized in moderate yields through the reaction of Nef-Adducts (α-keto imidoyl chlorides), which were generated from the interaction of N-cyclohexyl isocyanide with aryl carbonyl chlorides, followed by the incorporation of 2-aminopyridine. The imidazo[1,2-a]pyridin-4-ium chlorides produced were thoroughly characterized in this study, and the X-ray crystal structures of their salts were determined. This research examines the antimicrobial properties of the prepared compounds against various microbial strains. The findings suggest that compounds 7b and 7d exhibit the broadest and most potent activity.