DOI: 10.1039/d6cp01760f ISSN: 1463-9076
Nanoscale morphological and structural analysis of round and donut oligomers formed by C-terminal domain of TDP-43
Davis Pickett, Yana Purvinsh, Joshua T. Skrehot, Daniel Warren, Dmitry KurouskiAmyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease (AD), and Parkinson's disease are associated with an abrupt aggregation of TAR DNA-binding protein 43 (TDP-43).