DOI: 10.1039/d6cp00786d ISSN: 1463-9076
Mutations in the WFYY motif alter human PrimPol activity: structural insights from atomistic MD simulations
Sruthi Sudhakar, Vipin Kumar Mishra, S. Harikrishna, Sumon Naskar, P. I. PradeepkumarMutations in the WFYY motif impair the polymerase activity of human PrimPol, an enzyme involved in reinitiating DNA replication at the stalled replication forks, by altering intermodule communication and active site dynamics.