DOI: 10.1111/pde.70341 ISSN: 0736-8046
Much Ado About a Mutation: Congenital Melanocytic Nevus With
LINC00518
and Preferentially Expressed Antigen in Melanoma Positivity
Racquel A. Bitar, Tatiana F. Abrantes, Holly Neale, Birgitta A. R. Schmidt, Ingrid M. Ganske, Elena B. Hawryluk ABSTRACT
Small and medium sized congenital melanocytic nevi (CMN) have an overall low risk of malignant potential. This case demonstrates a pediatric patient with a small CMN positive for LINC00518 ( LINC ) and preferentially expressed antigen in melanoma ( PRAME ) on a non‐invasive molecular test not yet validated in children. Although her nevus had not evolved, the availability of a molecular test and curiosity ultimately raised concern about this otherwise reassuring, stable CMN. This demonstrates the pitfalls of non‐invasive testing in pediatric patients with CMN.