More Prominent 18F-FDG Uptake Than 68Ga-FAPI-04 in Nongestational Choriocarcinoma

Choriocarcinoma, a highly malignant trophoblastic tumor, usually follows a normal or abnormal pregnancy and is called gestational choriocarcinoma. The nongestational form, known as primary choriocarcinoma, is extremely rare in men. Herein, we report the ¹⁸ F-FDG and ⁶⁸ Ga-FAPI-04 PET/CT findings in a 56-year-old man with nongestational choriocarcinoma of unknown primary and multiple metastases. The lesions showed intense ¹⁸ F-FDG uptake but limited ⁶⁸ Ga-FAPI-04 accumulation.