Molecular Profile of Non-Small Cell Lung Carcinoma – An Institutional Study
Shubhika Rao Sachdeva, Bhavna Nayal, Ananth Pai, Shrinidhi NathanyIntroduction:
Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer, known for its diversity and variable treatment responses. Molecular profiling has emerged as a vital approach to understanding the genetic and epigenetic alterations driving NSCLC, facilitating more personalized therapeutic strategies.
Objectives:
This article aims to explore the current landscape of molecular profiling in NSCLC, focusing on identifying critical genetic mutations, biomarkers, and their implications for targeted therapies. We highlight the significance of genomic alterations in guiding treatment decisions and improving patient outcomes.
Materials and Method:
A retrospective study was conducted on NSCLC patients diagnosed via biopsy/resection from February 1, 2016 to August 15, 2019, at a South Indian tertiary care hospital. The molecular and mutational analysis data was obtained from Onquest laboratory reports following necessary permission. All cases were followed-up for a minimum of 3 years and responses to treatment and prognosis were analyzed.
Results:
Out of the 208 histologically diagnosed NSCLCs, 44 patients underwent molecular testing for
Conclusion:
Molecular profiling of NSCLC provides critical insights into the tumor biological behavior and guides personalized treatment plans. As research advances, integrating comprehensive molecular profiling into clinical practice will be essential for optimizing therapeutic strategies and enhancing NSCLC management, leading to better prognosis and innovative treatment modalities.