MOF on HOF NanoFilms for Efficient Bacteria Infected Wound Healing

ABSTRACT

The increasing severity of antibiotic‐resistant bacterial infections necessitates the development of next‐generation wound dressings capable of both potent antimicrobial activity and effective tissue repair. Porous organic framework materials possess stable structural connectivity, large specific surface areas, and well‐ordered pore architectures, making them promising platforms for applications in infectious wound healing. In this study, metal–organic framework (MOF) and hydrogen‐bonded organic framework (HOF) nanofilms (MOF‐on‐HOF) were successfully integrated onto medical gauze through van der Waals heterojunction interactions, enabling a synergistic cascade effect that enhances both antibacterial activity and wound regeneration. The MOF‐on‐HOF composite was uniformly loaded on gauze by utilizing the solution processability of HOF and the interfacial film‐forming ability of MOF. The resulting MOF‐on‐HOF dressing rapidly and efficiently eliminated Gram‐positive pathogens, thus demonstrating excellent antibacterial efficacy against Staphylococcus aureus (≥99%). Meanwhile, it facilitated hemostasis, scavenges reactive oxygen species (ROS), and accelerates cell migration. In a methicillin‐resistant Staphylococcus aureus (MRSA )‐infected wound model, treatment with MOF‐on‐HOF@guaze eradicated bacterial load on the wound surface, hence reduces the expression of pro‐inflammatory cytokines, and significantly promotes wound closure, achieving a wound healing rate of 98%. These results highlight the MOF‐on‐HOF@guaze as a promising platform for managing acutely infected wounds and combating antimicrobial resistance.