DOI: 10.1039/d6md00484a ISSN: 2632-8682

Modulating phosphorylation by proximity-inducing strategy: an update

Yuxin Xia, Daichao Zhai, Qidong You, Lei Wang, Qiuyue Zhang

Proximity-inducing chimeras bring kinases or phosphatases into proximity with selected proteins to modulate phosphorylation. This review highlights recent advances in PHICSs and PHORCs and outlines key design challenges for phosphorylation control.

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