Metabolic and Synthetic Biology Strategies for Enhancing Single‐Cell Protein Production in Saccharomyces cerevisiae

ABSTRACT

Single cell protein (SCP), distinguished by its high production efficiency, flexible substrate utilization, and excellent nutritional value, has broad application prospects in both feed and food sectors. With the advancement of synthetic biology and metabolic engineering, SCP is poised to become a mainstream protein source, providing key solutions for global food security and carbon neutrality goals. This review focuses on Saccharomyces cerevisiae as an SCP chassis and summarizes recent metabolic and synthetic biology strategies aimed at enhancing cellular protein content and cell biomass, thereby improving its potential for sustainable large‐scale protein production.