Metabolic and Digestive Functions of Glucagon-Like Peptide-1 in Pigs

Abstract

Glucagon-like peptide-1 (GLP-1) is a hormone with multiple biological effects that plays a key role in glucose metabolism, digestion, and energy homeostasis. In pigs, GLP-1 serves as an important metabolic regulator with relevance for both production efficiency and translational research. This review summarizes current knowledge on GLP-1 physiology in pigs, including synthesis, secretion, metabolism, and biological actions. Particular emphasis is placed on the role of GLP-1 in insulin secretion, digestive function, including gastric mucosal protection and ulcer prevention, appetite regulation, and lipid metabolism. Understanding GLP-1 mechanisms in pigs has practical implications for optimizing feeding strategies in swine production and provides insights relevant to human metabolic disease research.