Menopausal Symptoms in Natural and Surgical Menopause: Correlation with Serum Estradiol and Testosterone Levels
Shatakshi Gupta, Poonam Yadav, Nidhi Gupta, Ruchika Garg, Akrishti Gupta, Shivranjani Sahu
A
BSTRACT
Background:
Menopause is a physiological transition often associated with bothersome somatic, psychological, and urogenital symptoms. While natural menopause occurs gradually, surgical menopause results in abrupt hormone withdrawal, often leading to more severe symptoms. The extent to which serum estradiol and testosterone influence these symptoms remains inadequately defined in the Indian population.
Objectives:
The objectives of this study were to compare the severity and pattern of menopausal symptoms in women with natural and surgical menopause and to evaluate their correlation with serum estradiol and free testosterone levels.
Materials and Methods:
A comparative observational study was conducted over 2 years at Sarojini Naidu Medical College, Agra, involving 198 postmenopausal women (102 – natural and 96 – surgical) within 5 years of menopause. Menopausal symptoms were assessed using the Menopause Rating Scale (MRS). Serum estradiol and free testosterone were measured using chemiluminescence immunoassay. Data were analyzed using
Results:
Women with surgical menopause showed significantly higher total MRS scores across somatic, psychological, and urogenital domains (
Conclusion:
Surgical menopause is associated with a significantly greater burden of menopausal symptoms, closely linked to reduced estradiol levels. Hormonal profiling may guide personalized treatment strategies for improved symptom control.